Functional Peptides

A novel angiogenic peptide named AG30 (angiogenic peptide 30) was discovered in exploratory research at Osaka University^{1), 2)}. AG30 consists of 30 amino acids and has the unique pharmacological effects of angiogenesis and antimicrobial functions. Using AG30 as a basis and repeatedly modifying it to replace some of its amino acids, SR-0379 was created to exhibit those same pharmacological effects³⁾. In addition, adjuvant-like peptide "AJP001"⁴⁾ and antimicrobial peptide "Curepeptin" have been created after partial modification of amino acid sequences in AG30.

References
1) Nishikawa T, Nakagami H, Maeda A, et al: Development of a novel antimicrobial peptide, AG-30, with angiogenic properties. J Cell Mol Med. 2009: 13; 535-546
2) Nakagami H, Nishikawa T, Tamura N, Maeda A, Hibino H, Mochizuki M, Shimosato T, Moriya T, Morishita R, Tamai K, Tomono K, Kaneda Y. Modification of a Novel Angiogenic Peptide, AG30, for the Development of Novel Therapeutic Agents. J Cell Mel Med 2012 Jul;16(7):1629-1639
3) Tomioka H, Nakagami H, Tenma A, Saito Y, Kaga T, Kanamori T, Tamura N, Tomono K, Kaneda Y, Morishita R. Novel anti-microbial peptide SR-0379 accelerates wound healing via the PI3 kinase/akt/mTOR pathway. PLoS One 2014;9:e92597.
4) Tenma A，Nakagami H，Tomioka H，Sakaguchi M，Ide R，Koriyama H，Hayashi H，Shimamura M， Rakugi H，Morishita.，AJP001, a novel helper T-cell epitope, induces a humoral immune response with activation of innate immunity when included in a peptide vaccine. FASEB Bioadv. 2019 Nov 22;1(12):760-772.